You can use RadCartesianChart in MVVM scenarios like any other WPF control - you can bind the properties of the control that you want to change to corresponding properties in your ViewModel.
When you want to change some of the RadCartesianChart's settings, instead of recreating the control from scratch, you can just adjust the properties in your ViewModel. Adjusting them will update the corresponding properties in RadCartesianChart. For more complex scenarios you can use SeriesProvider feature. Here
you can learn more about it.
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