Our RadAjax "Prometheus" control is configured to update both the controls from the RadControls "Prometheus" and RadControls for ASP.NET package. You can see that from the integration examples under the Highlights section in the online demos:http://www.telerik.com/demos/aspnet/prometheus/Controls/Examples/Default/DefaultCS.aspx
Note that the old RadAjax framework can also update all Telerik controls. It is up to you to decide whether you want to choose the Telerik framework in combination with ASP.NET AJAX (t.e. RadAjax "Prometheus") or the standard version (RadAjax for ASP.NET).
the Telerik team