If you have RadGrid's databinding mechanism set up properly, you do not have to rebind the grid on paging. Here a couple of steps you need to ensure:
1. Your grid uses advanced databinding using the NeedDataSource event
2. You create your dynamic user control early enough for the postback events to take place and you ensure the control is properly recreated on postback before ViewState is restored to the controls collection.
If you share some sample code we can examine, we may be able to identify what exactly is causing this issue and give more specific suggestions for improvement. For now, it seems either the grid is not properly databound, or the entire user control is not recreated on postback.
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