I understood that the problem maybe is not directly related to Telerik control. I have asked you to host the site in IIS and/or test the same site on different Visual Studios installed on different machines in order to isolate the problem. Did you perform these test? If so, did the same error appear?
In general, you can disable script debugging in IE by checking the "Disables script debugging" (it is disabled by default). You need to open "Tools -> Internet Options -> Advanced" in order to do this. The checkbox (actually there are 2 checkboxes) is child of the "Browsing" node in the "Settings" tree. Please note that, however, this will not disable the error notification message of the browser.
I helps this helps.
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