In the current version of the RadComboBox control in order to disable specific items from being selectable you will need to set the IsEnabled property if the item. You can take a look at this
article that shows all of the available approaches in achieving the desired behavior.
Unfortunately in the current version of the control it is no possible to disable specific items without setting theirs IsEnabled property. Please let us know if we can be of any further assistance on this matter.
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