We cannot reproduce the described behavior. Controls which are content of RadBusyIndicator should regain their enabled state automatically, without a mouse hover. Please, chech RadBusyIndicator FirstLook example
I suppose what you are experiencing is a delay due to the amount of data being loaded. Maybe you could try optimizing the data loading or consider implementing additional RadBusyIndicator instances if the UI allows it, instead of a single RadBusyIndicator.
Please, send a reproducable sample if the problem persists.
All the best,
the Telerik team
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