Hi Yana,
Thanks for the sample. Unfortunately, it seemed that whenever we set the selected value or item to null, we got an error (Value '' could not be converted). I can understand this behaviour as the combobox had no corresponding null entry. In fact, this error occurred even with the RadComboBox's ClearSelectionButton.
We eventually got around this by using a converter on the SelectedValue binding of the control. The converter sets the value to -1 if a null is passed in. This works in our instance as the object is initialised with an ID (which is what the SelectedValuePath is set to) of -1.