I have this issue with DNN 4.9 also.
In the httpHandlers section:
<!-- Telerik Charting support -->
<add path="ChartImage.axd" verb="*" type="Telerik.Web.UI.ChartHttpHandler, Telerik.Web.UI,
Version=2008.2.1001.20, Culture=neutral, PublicKeyToken=121fae78165ba3d4" validate="false" />
The version is correct.
As per this forum I tried:
<!-- Telerik Charting support -->
<add path=",,/,,/ChartImage.axd" verb="*" type="Telerik.Web.UI.ChartHttpHandler, Telerik.Web.UI,
Version=2008.2.1001.20, Culture=neutral, PublicKeyToken=121fae78165ba3d4" validate="false" />
but then it doesn't think the handler has been added to the web.config.
What else can I try?