AUTHOR: Eyup Yusein
DATE POSTED: October 30, 2017
AJAX may sometimes hide both server and client-side errors. Therefore, when developing your app, we highly recommend you to ensure that the functionality works without adding AJAX. Quite a helpful way of troubleshooting your project could be if you remove AJAX on the page (if present) and enable your script debugger (FireBug or F12) to see whether there are any script or server errors interfering, and make sure that the application works without AJAX.
Also, note that using RadAjaxPanel/UpdatePanel simultaneously with RadAjaxManager or UpdatePanel (or implementing multiple wrapped RadAjaxPanels/UpdatePanels) is not a supported scenario and we highly recommend to avoid such implementation. In such cases you can replace the RadAjaxPanel with a regular asp:Panel or remove the RadAjaxManager:
Controls Wrapped in AjaxPanel and Added to AjaxManager Settings