Telerik RadGrid provides a full set of data items selection features on client-side and on server-side. You can also easily make your grid select single cells.
Telerik RadGrid also gives you a full control over the appearance of the selected items.
Client-side
On the client you can select the data using Ctrl key or just drag around the selection.

Server-side
On the server you can select the data using GridButtonColumn or GridCheckboxColumn
See Also