Telerik RadComboBox supports item tooltips which enables special accessibility readers like JAWS to pronounce the tooltip of the highlighted item. To set a ToolTip property assign it a string value.
Example

| ASPX |
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<rad:RadComboBox ID="RadComboBox1" runat="server"> <Items> <rad:RadComboBoxItem runat="server" Text="New York" ToolTip="New York"></rad:RadComboBoxItem> </Items> </rad:RadComboBox> |
| C# |
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RadComboBox1.Items[0].ToolTip = "New York"; |