The Rad Controls suite used in Sitefinity version 5.0 is version 2011.3 which means that the controls were developed and released in year 2011 Q3. The official release date of Internet Explorer 10 is 26.10.2012 with Windows 8. Therefore the controls in Sitefinity 5.0 might not be compatible with Internet Explorer 10.
I would suggest considering an upgrade to Sitefinity 5.4 or the upcoming in April 6.0 version, which comes with the latest released version of the controls that are fully compatible with Internet Explorer 10.
the Telerik team
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