The RadScheduleView supports the create, modify and delete operations out of the box if you use an ObservableCollection<Appointmnet> or any ObservableCollection<T> where T is a class with a parameterless constructor implementing the IAppointment interface as an AppointmentsSource. It doesn't support out-of-the-box integration with CRM 2011 and if any synchronization of the data source is needed you will need to implement it yourself.
Hope this information is helpful.
All the best,
the Telerik team