Never mind, I figure out how to use the SPRadGrid Designer with Binding Mode = "SPList" (for those interested, the explanation is in the sample site http://sharepoint.telerik.com/aspnet-ajax/web-parts/Pages/Telerik-SPRadGrid-Hierarchy.aspx
I have another issue though. I cannot figure out how to make the sorting/filtering work when binding to an SP list. My list has about 500 records. If I bind to a view which is paged, then the sorting/filtering seems to work only on the data in the current page, which is kind of useless. If I remove the paging in the view itself, then sorting/filtering works but the entire data set needs to load every time the page is loaded, and performance is terrible. Enabling or disabling the paging at the web part level seems to have little effect. How can I make it all work together so I can use sorting/filtering on a large data set?
Thanks in advance for taking the time to answer.