Have you tried using RadScriptManager? It will compress the output scripts uzing GZIP and will merge all files in one. Also make sure your web site runs in release mode <compilation debug="false"> in the web.config. Alternatively you can se the ScriptMode property of your scriptmanager control to "Release". This would enable the release (minified) scripts of ASP.NET Ajax which are substantially smaller.
We have thought of including the animation scripts only when needed. Perhaps we would be able to implement that feature for the next release.
the Telerik team
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