Hi Kendall Bennett,
You assumed correctly, all of the data access should be done via OpenAccess so you can 100% rely on the level 2 cache. If someone manually alters a record in the database, then a possibility for reading out-dated data is in place. And yes, if you have a web farm or some other multiple-server solution, the machines should be connected so that a request served on one of the machines can invalidate the cache on another one(via MSMQ).
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