What I assume is that you do not update the TargetControls collection when needed and it keeps the old values. To resolve the problem , please go through the following steps:
1) When you change the page, clear the TargetControls collection on the server by calling
2) If you have ajaxified the ListView, ajaxify the tooltip manager as well so that when the view with the targets gets updated, the manager also does.
In case you need further assistance, please prepare a fully runnable page (use a fake programmatic datasource if needed) and share its source code here along with detailed reproduction steps and explanations and I will help you get the desired result.
the Telerik team