Only one instance of RadSkinManager can be used one a single page. However, you have the TargetControls collection of the Skin manager where you can set different skins to different types of controls.
Attached is a small sample.
All the best,
the Telerik team
Registration for Q1 2011 What’s New Webinar Week is now open. Mark your calendar for the week starting March 21st and book your seat
for a walk through all the exciting stuff we ship with the new release!