AppBuilder helps you build hybrid cross platform applications designed for device deployment. The apps are based on Cordova
platform which provides different version regarding the OS. Thus said you will no be able to access device's native functions using the current app structure and build even if you succeed to deploy your app on server and open it from there. Following the link above you will notice that Cordova supports Windows (desktop), but I haven't tested it most probably because it is out of the scope of our current support service.
Here is a link
to a blog post that you may find interesting.
Share what you think about AppBuilder and Telerik Platform with us in our feedback portal, so we can become even better!