No, Mac OS X compatibility is not on our roadmap. You can only install Test Studio in Windows. You can run Windows on a Mac using a program like Parallels Desktop, however.
You can execute a Test Studio test against the Windows version of Safari, however.
You may also be interested in Test Studio for iOS. You can test against the mobile version of Safari on iOS devices or the device simulator on a Mac. See here for our user's guide articles on Mobile Testing.
the Telerik team