Yes, you can achieve the desired functionality. Please refer to the following online demo, where the basics of the drag&drop between TreeViews and other elements is demonstrated.
Regarding the need to disable the drag from the RadTreeView2 to RadTreeView1 - you can use the onNodeDropping client-side event. Then in you can get the ID of the source TreeView, using the sender.get_id(). and the destination, using dest.get_treeView().get_id(). If the attempt of draging is TreeView2->TreeView1 you can cancel the event, using the eventArguments: args.set_cancel(true);
As for the Drag&Drop between nodes - you can use the property EnableDragAndDropBetweenNodes regarding the desired behavior for each TreeView.
Hope this information helps.
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