If you like to filter the working days of the week you could do it as shown in our demo. For your case you need to filter the working days and not the weekends.
As to the second question - you cannot set different working hours for each day, but you could set DayStartTime and DayEndTime properties of each ViewDefinition in order to set working hours for the whole week.
I hope this helps.
All the best,
the Telerik team