With one of our internal builds we introduced a new property of GridViewColumn named TabStopMode which will be very helpful in scenarios like yours. This property is a flag enumeration with 4 possible values - Skip, StopInViewMode, StopInEditMode and Stop (default which combines the other two stop options). TabStopMode will become official with the upcoming service pack (in a couple of weeks).
You can handle mouse left button down event and focus another cell accordingly (depending on its frozen state). Since that Enter key navigates down or upwards there is no way to configure some custom behavior via GridViewColumn. I could suggest you to take a look at this blog post which shows how you can change the default keyboard command behavior.
I'm attaching a sample application that demonstrates TabStopMode and mouse left button click handler approaches.
Let me know if you need any further assistance.
All the best,
the Telerik team
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