The error you are reporting is a device connectivity one. AppBuilder cannot seem to get through to the devices.
Here are the things you can do to work around those.
The easiest thing to do is to restart Visual Studio and reconnect your device.
If this does not help and you still get the port errors, you might try resetting the device pairing. Here's how to do that:
1. Select AppBuilder -> Options -> iOS.
2. In the Paired Devices panel, click Reset and confirm the operation.
3. Click Save (this is essential).
4. Reconnect your device.
5. Try Build and Deploy again.
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